Anti PGE2 Recombinant Monoclonal Antibody (2B5)

Overview
The Anti-PGE2 Recombinant Monoclonal Antibody (Clone 2B5) is a high-affinity mouse antibody specifically developed for the detection and functional neutralization of prostaglandin E2 (PGE2). Produced in CHO cells, this recombinant antibody is validated for immunohistochemistry, Western blot, and ELISA applications, making it an essential tool for research in inflammation, fever, bone metabolism, and reproductive biology.

Background
Prostaglandin E2 (PGE2) is a key lipid mediator involved in a wide range of physiological and pathological processes, including inflammation, fever induction, uterine contraction during labor, cervical ripening, and bone remodeling via osteoblast-osteoclast interactions. PGE2 also modulates immune responses by suppressing T-cell receptor signaling and contributes to the resolution of inflammation.

Research Applications
Ideal for:

• Inflammation and immune modulation studies

• Fever and thermoregulation research

• Bone metabolism and osteoclast/osteoblast interactions

• Reproductive biology and parturition studies

• Pain and nociception research

• Cancer microenvironment and tumor-associated inflammation

Note: For research use only. Not for diagnostic use.