Anti-TNF alpha antibody (AA 181-235)

The Medikbio anti-TNF alpha antibody (AA 181–235) – Catalog No. MDB677318 is a high-quality rabbit polyclonal antibody specifically developed to detect Tumor Necrosis Factor alpha (TNF-α), a key pro-inflammatory cytokine central to immune regulation, inflammation, apoptosis, and NF-κB signaling. This antibody is validated for use in Western Blot (WB), ELISA, Immunohistochemistry (IHC-P/IHC-F), and Immunofluorescence (IF), delivering strong sensitivity, clean background, and reproducible results across multiple tissue types and species.

Produced using a KLH-conjugated synthetic peptide derived from mouse TNF-α, this antibody demonstrates excellent reactivity with Human, Mouse, Rat, Horse, and Rabbit, making it suitable for translational studies and multi-model research. Purified using Protein A chromatography, the antibody provides high specificity toward TNF-α, a cytokine known to modulate fever, promote cytokine secretion, stimulate apoptosis, drive inflammation, and regulate immune cell differentiation.

TNF-α plays a major role in diseases such as autoimmune disorders, cancer, chronic inflammation, infectious diseases, metabolic disorders, and corneal inflammation. With published applications in leading journals—including PLOS ONE, Angiogenesis, Cytokine, and Journal of Inflammation Research—this antibody is highly trusted within the scientific community for studying NF-κB signaling, TLR pathways, apoptosis, inflammasome activation, and immune effector functions.