The Anti-TGFB1 Rabbit Monoclonal Antibody (MD5A123) is a highly specific, unconjugated antibody designed to detect Transforming Growth Factor Beta 1 (TGFB1) at amino acids 351–390. Validated across a wide range of applications including Western Blot, ELISA, Immunohistochemistry, Immunofluorescence, and Flow Cytometry, this antibody is essential for research in fibrosis, cancer biology, immunology, and developmental studies.
Background
TGFB1 is a secreted multifunctional cytokine that regulates cell proliferation, differentiation, immune responses, and extracellular matrix production. It plays critical roles in wound healing, fibrosis, cancer progression, bone remodeling, and autoimmune regulation. Dysregulation of TGFB1 is associated with numerous diseases, making it a key target in therapeutic and mechanistic research.
Research Applications
Ideal for:
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Fibrosis and tissue remodeling studies
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Cancer microenvironment and metastasis research
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Immunoregulation and autoimmune disease models
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Bone development and osteoblast differentiation
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Cardiovascular and renal pathophysiology
Pathways Involved
EGFR signaling, autophagy, immune checkpoint regulation, muscle differentiation, glycosaminoglycan metabolism, and more.
Note: For research use only. Not for diagnostic or therapeutic use.
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